Cdkn2a CLIA Kit for Mouse(Mus musculus) | EIAab.comCdkn2a CLIA Kit for Mouse(Mus musculus)

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Cdkn2a (Gene name),

Cyclin-dependent kinase inhibitor 2A, isoforms 1/2 (Protein name ), CD2A1_MOUSE from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

Cdkn2a(P16ink4a);

Protein name:

Cyclin-dependent kinase inhibitor 2A, isoforms 1/2;

Alternative:

p16-INK4a(p16-INK4);Cyclin-dependent kinase 4 inhibitor A(CDK4I);

Organism:

Mouse (Mus musculus).

General Annotation

Sub Unit:

Heterodimer with CDK4 or CDK6. Predominamt P16 complexes contained CDK6. Interacts with CDK4 (both 'T-172'-phosphorylated and non-phosphorylated forms); the interaction inhibits cyclin D-CDK4 kinase activity. Interacts with ISCO2.

Function:

Acts as a negative regulator of the proliferation of normal cells by interacting strongly with CDK4 and CDK6. This inhibits their ability to interact with cyclins D and to phosphorylate the retinoblastoma protein.

Subcellular Location:

Cytoplasm Nucleus

Protein Attributes:

Sequence length:

168

Sequence:

50:

100:

150:

168:

SSSTPRALEL | RGQSQEQS

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

SMR:

P51480

KEGG:

mmu:12578

UniGene:

Mm.4733

Pfam:

PF00023

String:

P51480

Pfam:

PF12796

Uniprot:

P51480

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ELISA Kit for Mouse Cyclin-dependent kinase inhibitor 2A, isoforms 1/2

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E0794h

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96T

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ELISA Kit for Mouse Cyclin-dependent kinase inhibitor 2A, isoforms 1/2

Cat.:

E0794r

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ELISA Kit for Mouse Cyclin-dependent kinase inhibitor 2A, isoforms 1/2

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E0794m

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96T

CLIA Kit for Mouse Cyclin-dependent kinase inhibitor 2A, isoforms 1/2

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U0794r

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96T

CLIA Kit for Mouse Cyclin-dependent kinase inhibitor 2A, isoforms 1/2

Cat.:

U0794h

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MSDS:

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Packing:

96T

CLIA Kit for Mouse Cyclin-dependent kinase inhibitor 2A, isoforms 1/2

Cat.:

U0794m

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96T

Polyclonal Antibody for Mouse Cyclin-dependent kinase inhibitor 2A, isoforms 1/2

Cat.:

P0794Rb-m

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40ug/0.2ml

Polyclonal Antibody for Mouse Cyclin-dependent kinase inhibitor 2A, isoforms 1/2

Cat.:

P0794Rb-r

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Polyclonal Antibody for Mouse Cyclin-dependent kinase inhibitor 2A, isoforms 1/2

Cat.:

P0794Rb-h

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Packing:

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Monoclonal Antibody for Mouse Cyclin-dependent kinase inhibitor 2A, isoforms 1/2

Protein for Mouse Cyclin-dependent kinase inhibitor 2A, isoforms 1/2

R&D Technical Data

12% SDS-PAGE Analysis

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

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Recovery

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Linearity

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References

1.

"Cloning and characterization of murine p16INK4a and p15INK4b genes."
Quelle D.E. , Ashmun R.A. , Hannon G.J. , Rehberger P.A. , Trono D. , Richter K.H. , Walker C. , Beach D. , Sherr C.J. , Serrano M.
Oncogene11:635-645(1995) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
2.

"Cdkn2a, the cyclin-dependent kinase inhibitor encoding p16(INK4a) and p19(ARF), is a candidate for the plasmacytoma susceptibility locus, Pctr1."
Zhang S. , Ramsay E.S. , Mock B.A.
Proc. Natl. Acad. Sci. U.S.A.95:2429-2434(1998) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);VARIANTS PRO-18; ILE-51; MET-74; TYR-75 AND ARG-90
strain: BALB/c.
strain: DBA/2N.
tissue: Spleen.
3.

"Cloning and structure analysis of murine p16INK4a."
Gong Z. , Li J. , Fu J.
Submitted (2000-12) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
strain: 129/SvJ.
4.

"The transcriptional landscape of the mammalian genome."
Carninci P. , Kasukawa T. , Katayama S. , Gough J. , Frith M.C. , Maeda N. , Oyama R. , Ravasi T. , Lenhard B. , Wells C. , Kodzius R. , Shimokawa K. , Bajic V.B. , Brenner S.E. , Batalov S. , Forrest A.R. , Zavolan M. , Davis M.J. , more...
Science309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
5.

"Lineage-specific biology revealed by a finished genome assembly of the mouse."
Church D.M. , Goodstadt L. , Hillier L.W. , Zody M.C. , Goldstein S. , She X. , Bult C.J. , Agarwala R. , Cherry J.L. , DiCuccio M. , Hlavina W. , Kapustin Y. , Meric P. , Maglott D. , Birtle Z. , Marques A.C. , Graves T. , Zhou S. , more...
PLoS Biol.7:E1000112-E1000112(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
strain: C57BL/6J.
6.

"Inactivation of the cyclin-dependent kinase inhibitor p15INK4b by deletion and de novo methylation with independence of p16INK4a alterations in murine primary T-cell lymphomas."
Malumbres M. , de Castro I.P. , Santos J. , Melendez B. , Mangues R. , Serrano M. , Pellicer A. , Fernandez-Piqueras J.
Oncogene14:1361-1370(1997) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-155
strain: C57BL/6J X DBA.
7.

"Comparative analysis of the p16(INK4a) and p15(INK4b) DNA sequences in mouse inbred strains."
Santos J. , Melendez B. , Perez de Castro I. , Malumbres M. , Serrano M. , Pellicer A. , Fernandez-Piqueras J.
Submitted (1996-10) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-155;VARIANTS PRO-18; ILE-51; GLN-90 AND SER-127
strain: BALB/cJ.
strain: C57BL/6J.
strain: CAST/Ei.
strain: MOLF/Ei.
strain: RF/J.
8.

"Sequence variation and chromosomal mapping of the murine Cdkn2a tumor suppressor gene."
Herzog C.R. , You M.
Mamm. Genome8:65-66(1997) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-42 (ISOFORM 1);VARIANT PRO-18
strain: 020.
strain: 129/J.
strain: A/J.
strain: A/Wy.
strain: AKR/J.
strain: B10.A.
strain: B10.D2(58N).
strain: BALB/c.
strain: C3H/21BG.
strain: C3H/HeJ.
strain: C57BL/10SCN.
strain: C57BL/10SN.
strain: C57BL/6By.
strain: C57BL/6J.
strain: C57BR/cdJ.
strain: CBA/J.
strain: DBA/2J.
strain: HS/IBG.
strain: LP/J.
strain: LS/IBG.
strain: MA/M4J.
strain: PL/J.
strain: RF/J.
strain: Sencar.
strain: SJL/J.
strain: SM/J.
strain: ST/J.
strain: SWR/J.
tissue: Lung.
9.

"Induction of mutations in Ki-ras and INK4a in liver tumors of mice exposed in utero to 3-methylcholanthrene."
Gressani K.M. , Rollins L.A. , Leone-Kabler S. , Cline J.M. , Miller M.S.
Carcinogenesis19:1045-1052(1998) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-42;VARIANTS VAL-12; GLU-27 AND LEU-73
10.

"Cancer-associated mutations at the INK4a locus cancel cell cycle arrest by p16INK4a but not by the alternative reading frame protein p19ARF."
Quelle D.E. , Cheng M. , Ashmun R.A. , Sherr C.J.
Proc. Natl. Acad. Sci. U.S.A.94:669-673(1997) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: MUTAGENESIS OF CYS-64; ASP-76 AND 84-ASP-THR-85

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